The line begins to form before sunrise outside Zuckerberg San Francisco General Hospital, with some people arriving as early as 2 a.m., bringing fold-up chairs and blankets to protect against the Bay Area's overnight chill.

They wear face masks, and keep a social distance from others, obeying the ground rules from the early days of the Covid-19 pandemic -- when the desperate need for vaccines far outweighed what federal and state governments could supply.

CNN's Harmeet Kaur, Augie Martin, Jen Christiansen, Carma Hassan, and Carolyn Sung contributed to this story.

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